Played up to sequence 3 of the main story, must say its a bit confusing, or perhaps its just me.
The controls for the gun and melee are real weird, the reload on the musket is real long, you only have time to shoot one guy before swapping to your sword or pistol, makes the missions where you must use musket to get 100% sync take a long time. In sequence 2 where you have to free some prisoners its hard to get 100% because they don't tell you who or what the commander looks like.
Other than that, I Haven't come across any problems, gonna continue playing it and get as far as I can.
So far its an amazing game, only reason is stopped playing last night was because I got real tired
*ADDED 11/4/12*
I think i'm up to Sequence 7 or 8, getting used to the controls now