Reminds me of a long story, but I'll post the short version for y'all!:
As a Science Fair experiment in HS this guy built goggles that inverted his vision: up was down and down was up. He wore a blind mask which he donned and removed in darkness only (his closet) at night, when he slept, soas to not accidentally see the world right-side-up.
He spent his entire waking time with the things on. They looked absolutely geeky - like he had two toilet-paper tubes attached to some cheep-o eye-protection goggles, and it was all painted black, and held together with black electrician's tape.
It was HILARIOUS to see him in the first place, but to watch him STEPPING OVER THE CEILING LIGHTS as he walked the hallways between classes was enough to make you double over in laughter-pain! (My favorite was watching his UTTER FAILURE trying to get a drink from the wall-mounted drinking fountain! Leaning over, puckering to drink and then lifting his head UP, AWAY from the water stream, then correcting, then up and away again....
)
It turns out that what the learned in this area say is really true: After a little more than two weeks he/his brain adapted and he could do pretty-much everything normally again! (As "normal" as this guy was....
) [It's quite amazing actually that we can adapt that fast, isn't it?!?]
Anyway, I always think of that guy whenever I think about "mouse inversion:" It all depends on what your related learning environment was! (Myself, I tried it in some video games once and quickly realized that it wasn't for me!)
P.S. So JD:... are you LEFT-HANDED, too??