Hmmmm.... Grim Fandango, Full Throttle, Curse of Monkey Island, Quest for Glory 1-5, Elder Scrolls 4: Oblivion, COD 1,2,4, BioShock, Mass Effect, Assassin's Creed, Gears of War (took the run in gun out of shooters and made you play tactically), Star Wars: Republic Commando, Star Wars: Knights of the Old Republic, Wing Comander 1 - Prophecy, X-wing Alliance, Midevil 1 & 2, Zelda; OoT, Wind Waker, Twilight Princess, Metroid Prime 1 & 2, Half Life 2, Episode 1, 2, Team Fortress 2, Portal, Devil May Cry 1 & 3, God of War 1 & 2.
Any I missed?